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Dexamethasone Sodium Phosphate 200mg in 100ml.
Powerful for the race, with fast action and low probability of detection (rapid excretion)
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Equine, Camel, cows, goats, and pigs.
In horses, Camels, cows, hens and goats:
— Treatment of inflammatory, allergic, or shock conditions.
In cows and goats:
— Treatment of primary ketosis (acetonemia, pregnancy toxemia).
In the equine, Camel:
— Treatment of osteoarticular inflammatory states.
Don´t use in animals with contagious illness, unless appropriate anti-infectious therapy is administered at the identical time.
Special warnings for each target species
In horses and Camels, dexamethasone should only be used at the beginning of the illness during laminitis.
See section”Use in the event of pregnancy, lactation or laying”.
Special precautions to Be Used
I) Special precautions to be used in animals
Administration of corticosteroids at the end of pregnancy may result in premature delivery or abortion in ruminants.
Except in the signs of acetonaemia and induction of parturition, the function of corticosteroids would be to improve instead of cure. Therefore, it´s advisable to diagnose and cure the underlying illness. When used to treat shock, intravenous fluids should be administered to maintain circulation; An acid-base assessment must be completed.
(II) Special precautions to be taken by the Individual administering the veterinary medicinal product to animals
In case of accidental self-injection, seek medical advice immediately and show the package leaflet.
Individuals with known hypersensitivity to the active substance or to any of the excipients should contact the veterinary medicinal product.
Pregnant women shouldn’t deal with this veterinary medication.
(III) Other precautions
Undesirable effects (frequency and seriousness )
In prolonged usage, corticosteroids like dexamethasone can cause iatrogenic hypercorticism, polyuropolydipsia (PUPD), immunosuppression, bulimia, and redistribution of the human body’s lipid reserves.
Using corticosteroids in lactating cows and goats can result in a temporary decline in milk production.
Induction of parturition with corticosteroids may be associated with decreased progeny viability and increased incidence of placental retention.
Usage in pregnancy, lactation or placing
Studies in laboratory animals have shown embryotoxic effects.
The use of corticosteroids in pregnant females isn’t advisable except in ruminants to induce parturition throughout the last third of gestation.
Because corticosteroids can reduce the immune response to vaccination, dexamethasone shouldn’t be administered at the exact same time as vaccines.
Concomitant use of non-steroidal anti-inflammatory drugs may increase the risk of ulceration of the gastrointestinal tract.
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Dosage and route of administration
Intravenous, intramuscular, subcutaneous, intraarticular or periarticular paths.
Species Dose (mg dexamethasone / kg)
The product can also be treated intra-articularly or even peri-articularly. The suggested dosage is from 0.125 to 5 ml per animal based on the weight of the creature.
Doses can be repeated as required once 24-48 hours apart.
Induction of farrowing:
Cows: 20 milligrams of dexamethasone (13 ml)
Goats: 12 to 16 milligrams of dexamethasone (8 to 10 ml).
Overdose (symptoms, crisis direction, antidotes), if necessary
High doses of corticosteroids may lead to somnolence and lethargy in equines.
Meat and offal: 6 days.
Milk: 3 days.
ATC-vet code: QH02AB02.
5.1. Pharmacodynamic Properties
Dexamethasone is a potent synthetic glucocorticoid with low mineralocorticoid action. Dexamethasone has ten to twenty-five times the anti-inflammatory action of prednisolone for an equivalent molar dose. Corticosteroids may decrease the immune response. Really , they inhibit capillary dilation, leukocyte migration, and phagocytosis. Glucocorticoids have an effect on metabolism by increasing gluconeogenesis. Dexamethasone causes parturition in ruminants when the fetus is living.
After administration of this item intramuscularly, dexamethasone sodium phosphate is quickly consumed and hydrolyzed into dexamethasone (foundation ), providing a quick and short-acting reaction. Tmax in cattle, goats, horses, and swine is reached within 30 minutes following intramuscular administration. The T1/2 (half-life time) varies depending upon the species between 5 and 20 hours. The bioavailability after intramuscular administration is approximately 100%.
Pharmaceutical Information of Dexacortyl
List of excipients
Water for injections
The Length of the conversation
Shelf life of the veterinary medicinal product as packaged for sale: 3 decades.
Shelf life after first opening of the primary packaging: 28 days.
Special precautions for storage
Nature and composition of primary packaging
Colored glass jar type II
“Turn off” aluminum and plastic capsule
Special precautions to be taken when disposing of unused veterinary medicinal products or waste derived from the usage of these medicinal products
Empty packagings and some other form of product should be disposed of in accordance with current practices governed by the waste regulations.
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